Drugs & Vitamins

Kayexalate Active Ingredients: Sodium Polystyrene Sulfate Representative Names: Kayexalate, Kionex Available Product Images: What is polystyrene powder? What should I tell my health care provider before I take this medicine? How should I take this medicine? What if I miss a dose? What drug(s) may interact with polystyrene? What side effects may I notice from taking polystyrene? What should I watch for while taking polystyrene? Where can I keep my medicine? What is polystyrene powder? (Back to top) POLYSTYRENE (Kayexalate®) treats a condition called hyperkalemia, in which there is too much potassium in the body (blood). Polystyrene is an ion-exchange resin that loses sodium ions, that are replaced by potassium ions. Polystyrene powder can be made into an oral suspension (to be taken by mouth) or into an enema (for rectal use). Generic polystyrene powder is available. What should I tell my health care provider before I take this medicine? (Back to top) They need to know if you have any of these conditions: •constipation or a stomach or bowel obstruction •frequent use of laxatives •low levels of calcium or potassium in the blood •restricted sodium diet •an unusual or allergic reaction to polystyrene, other medicines, foods, dyes, or preservatives •pregnant or trying to get pregnant •breast-feeding How should I take this medicine? (Back to top) Polystyrene powder is not usually for self-administration. It may be given in a hospital or clinic setting. For oral (by mouth) use, polystyrene powder is mixed with a small quantity of water. The amount of water depends on the dose given and can range from 20 to 100 ml (about half an ounce to three ounces). The suspension must be freshly prepared and should not be stored for more than 24 hours. Alternatively a suspension of polystyrene can be given as an enema (into the rectum). Follow the directions on the prescription label. Take your medicine as directed. Do not take more often than directed. Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed. What if I miss a dose? (Back to top) If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses. What drug(s) may interact with polystyrene? (Back to top) •antacids •calcium salts •heart medicine •insulin •sodium bicarbonate •sorbitol •water pills Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines. What side effects may I notice from taking polystyrene? (Back to top) Side effects that you should report to your prescriber or health care professional as soon as possible: •confusion •depression. irritability •difficulty breathing, shortness of breath •increased thirst •irregular heartbeat, or chest pain •muscle spasms or muscle cramps •passing large amounts of urine •rectal or lower stomach pain •severe constipation or diarrhea •unusual swelling or water retention •unusual weakness Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome): •mild constipation or diarrhea •loss of appetite •nausea, vomiting What should I watch for while taking polystyrene? (Back to top) Polystyrene can affect the balance of many salts and water in your body, and these can affect normal working of the heart. Patients receiving polystyrene should be carefully monitored for changes in salt levels in the blood and for heart problems. Elderly patients are more susceptible to the effects of constipation induced by polystyrene. Do not treat constipation yourself; call your prescriber or health care professional for advice. Patients on sodium-restricted diets should take polystyrene with caution. You will also need to follow a low-potassium diet to prevent additional problems. Discuss dietary recommendations with your prescriber or health care professional, and follow these carefully. Where can I keep my medicine? (Back to top) Keep out of the reach of children. Store the dry powder at room temperature, between 15 and 30 degrees C (59—86 degrees F). After mixing the suspension, use within 24 hours. Throw away any unused suspension. Throw away unused powder after the expiration date. Last Updated:03/23/2004 CLINICAL PHARMACOLOGY© GOLD STANDARD MULTIMEDIA INC, ALL RIGHTS RESERVED

Note: The above information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist, or other healthcare professional. It should not be construed to indicate that the use of the product is safe, appropriate, or effective for you. Consult your healthcare professional before taking the product.